I N T E G R A L I S ®
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H2O2
ROS
O2
OH
OH
H2O2
O2
H2O2
O2
H2O2
OH
H2O2
OH
H2O2
ROS
O2
OH
OH
H2O2
O2
H2O2
O2
H2O2
OH
H2O2
OH
H2O2
ROS
O2
OH
OH
H2O2
O2
H2O2
O2
H2O2
OH
H2O2
OH
Scheme of the microbiological effect of 405 nm light on bacteria.
Researchers have hypothesized that violet-blue light may induce a
photo-oxidative stress in several pathogenic bacterial species.
Bacterial endogenous molecules could be excited by violet-blue light
and induce the rising of ROS (reactive oxygen species).
ROS, such as hydrogen peroxide and OH (hydroxil radical), destroy
macromolecules such as DNA, RNA, proteins, lipids and compromise
the cellular integrity, causing bacterial death.
Regarding viruses, in particular Sars-CoV2, scientific laboratory
tests conducted by Artemide have shown that the wavelength 405
nm contributes to the reduction of the viral load.
Infact, within the first four hours time, by using blue-light the
riduction is 35% bigger than the natural virus delay.
Further scientific studies are underway to investigate these results.
Microbiological action
against bacteria
Microbiological action
against viruses
In studying the effects of light on bacteria and viruses, Artemide has
been supported by the expertise of specialized research institutes
such as the University of Insubria and the University of Padua.
In addition to the knowledge of the scientific evidence on the
effects of light on potential pathogenic microorganisms, these
collaborations have contributed to transfer the scientific evidence
into applied research to design and verify the proprietary technology
INTEGRALIS®.
Scientific know-how
Hypotethical mechanism of photo-oxidative stress induced
by blue light in bacterial cells.
A. The irradiation of bacterial cell induces the
activation of endogenous photosensitizer
(grey dots).
B. Arising of reactive oxygen species (ROS)
such as hydrogen peroxide (H2O2), OH
(hydroxyl radical) and O2 (superoxide anion).
C. Biomolecules degradation and,
as a consequence, bacterial death.
